Pulsed electromagnetic field for early osteoarthritis
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【摘 要】BACKGROUND AND OBJECTIVE Osteoarthritis (OA) is a common and growing diagnosis encountered by physicians. Pulsed e- lectromagnetic fields (PEMFs) are known to modulate the calmodulin (CaM) dependent nitric oxide (NO)/cyclic guanosine monophosphate (eGMP) signaling pathway, impacting pain in patients with OA. This study was designed to determine whether PEMF, configured to modu- late the CaM/NO/cGMP signaling pathway, can reduce pain among patients with early knee OA.